Australian Museum Journal Potential role of human restriction factors in inhibiting the emergence of koala retrovirus (KoRV) as a zoonotic agent

Shortform:
Xu et al., 2014. Tech. Rep. Aust. Mus., Online 24: 79–81
Author(s):
Wenqin Xu; Tiffany Blankenship; Maribeth V. Eiden
Year published:
2014
Title:
Potential role of human restriction factors in inhibiting the emergence of koala retrovirus (KoRV) as a zoonotic agent
Serial title:
Technical Reports of the Australian Museum (online)
Volume:
24
Start page:
79
End page:
81
DOI:
10.3853/j.1835-4211.24.2014.1621
Language:
English
Date published:
29 May 2014
Cover date:
29 May 2014
ISSN:
1835-4211 (online)
Publisher:
The Australian Museum
Place published:
Sydney, Australia
Subjects:
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized:
29 May 2014
Available online:
29 May 2014
Reference number:
1621
EndNote package:
EndNote file
Title page:
Title page (164kb PDF)
Complete work:
Complete work (328kb PDF)

Abstract

The findings of an exogenous koala retrovirus (KoRV) associated with neoplastic diseases in koalas (Phascolarctos cinereus) brought up the concerns of infection by koala retroviruses in humans, especially koala handlers. As simple retroviruses, koala retroviruses lack the regulatory genes to counter restriction activities by human restriction factors in viral replication. Koala retroviruses belong to gammaretroviruses. Previous studies of susceptibility of murine leukemia virus and a lab contaminant retrovirus, gammaretroviral xenotropic MLV-related virus, to human restriction factors disprove the possibility of gammaretrovirus as a human pathogen. There is no evidence that the koala retrovirus can infect and replicate in human peripheral blood mononuclear cells, which is consistent with the resistant role of human restriction factors against gammaretroviruses.

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