Australian Museum Journal How does koala retrovirus (KoRV) induce disease at the genomic level?

Shortform:
Neil, 2014. Tech. Rep. Aust. Mus., Online 24: 57–58
Author(s):
James C. Neil
Year published:
2014
Title:
How does koala retrovirus (KoRV) induce disease at the genomic level?
Serial title:
Technical Reports of the Australian Museum (online)
Volume:
24
Start page:
57
End page:
58
DOI:
10.3853/j.1835-4211.24.2014.1616
Language:
English
Date published:
29 May 2014
Cover date:
29 May 2014
ISSN:
1835-4211 (online)
Publisher:
The Australian Museum
Place published:
Sydney, Australia
Subjects:
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized:
29 May 2014
Available online:
29 May 2014
Reference number:
1616
EndNote package:
EndNote file
Title page:
Title page (152kb PDF)
Complete work:
Complete work (300kb PDF)

Abstract

This manuscript summarizes the break-out session held on how does koala retrovirus (KoRV) induce disease at the genomic level at the Koala Conservation Workshop: The koala and its retroviruses: implications for sustainability and survival held at San Diego Zoo, April 17–18, 2013. The goals of this break-out session were to review current knowledge in this area and identify studies required to fill important gaps. KoRV is a gammaretrovirus with close similarity to MLV and FeLV, well-characterized pathogens of the laboratory mouse and the domestic cat. The parallel wth FeLV is particularly striking as cats harbor related endogenous retroviruses that share receptor specificity with endogenous KoRV. Also, transmission and pathogenesis of FeLV in its natural host is well understood and the virus is routinely controlled by measures that include vaccines. Alternative models for the roles of endogenous and exogenous KoRV in disease were discussed and prospective studies required to test these hypotheses were outlined.

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