Australian Museum Journal Prevention and treatment of koala retrovirus (KoRV) infection: lessons from studies of AIDS viruses in nonhuman primate models

Shortform:
Lifson, 2014. Tech. Rep. Aust. Mus., Online 24: 65–69
Author(s):
Jeffrey D. Lifson
Year published:
2014
Title:
Prevention and treatment of koala retrovirus (KoRV) infection: lessons from studies of AIDS viruses in nonhuman primate models
Serial title:
Technical Reports of the Australian Museum (online)
Volume:
24
Start page:
65
End page:
69
DOI:
10.3853/j.1835-4211.24.2014.1619
Language:
English
Date published:
29 May 2014
Cover date:
29 May 2014
ISSN:
1835-4211 (online)
Publisher:
The Australian Museum
Place published:
Sydney, Australia
Subjects:
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized:
29 May 2014
Available online:
29 May 2014
Reference number:
1919
EndNote package:
EndNote file
Title page:
Title page (161kb PDF)
Complete work:
Complete work (835kb PDF)

Abstract

The presence of multiple retroviruses in koalas (Phascolarctos cinereus), including viruses with exogenous infectious forms that may be associated with malignant disease manifestations, poses challenges for both management of captive populations and species preservation in the wild. The development of antiretroviral medications (ARV) for the treatment of human immunodeficiency virus (HIV) infection is one of the triumphs of modern medicine, and many of these drugs have relatively broad antiretroviral activity, suggesting they might be active against koala retroviruses (KoRVs). However, accumulating experience with the use of these medications in non-human primate (NHP) models of HIV infection and acquired immune deficiency syndrome (AIDS) points out several caveats and provides guidance in attempting to use anti-HIV drugs in the treatment of retroviral infection in nonhuman species. This manuscript reviews that experience from the perspective of potential use of ARVs for prevention and treatment of KoRV infection.