Australian Museum Journal Leukemogenesis by murine leukemia viruses: lessons for koala retrovirus (KoRV)

Shortform:
Fan, 2014. Tech. Rep. Aust. Mus., Online 24: 83–88
Author(s):
Hung Fan
Year published:
2014
Title:
Leukemogenesis by murine leukemia viruses: lessons for koala retrovirus (KoRV)
Serial title:
Technical Reports of the Australian Museum (online)
Volume:
24
Start page:
83
End page:
88
DOI:
10.3853/j.1835-4211.24.2014.1622
Language:
English
Date published:
29 May 2014
Cover date:
29 May 2014
ISSN:
1835-4211 (online)
Publisher:
The Australian Museum
Place published:
Sydney, Australia
Subjects:
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized:
29 May 2014
Available online:
29 May 2014
Reference number:
1622
EndNote package:
EndNote file
Title page:
Title page (167kb PDF)
Complete work:
Complete work (449kb PDF)

Abstract

Murine leukemia viruses (MuLVs) are the prototypical gammaretroviruses, and they have been extensively studied with regard to how they cause disease. Leukemogenesis by two MuLVs is reviewed here: the endogenous Akv MuLV of AKR mice, and exogenous Moloney MuLV. Important features of MuLV leukemogenesis include the in vivo generation of envelope recombinants (MCFs) through recombination with endogenous MuLVs, and induction of preleukemic changes typified by splenic hyperplasia secondary to bone marrow defects. Studies of MuLV leukemogenesis help to frame virological questions about how koala retrovirus (KoRV) may induce neoplastic or other diseases in koalas.